Variation in carotid-femoral pulse wave velocity, augmentation pressure and augmentation index during different phases of menstrual cycle

Indicators of arterial stiffness during phases of menstrual cycle

  • Nudrat Kahkashan Deccan College of Medical Sciences
  • Mehnaaz Sameera Arifuddin Deccan College of Medical Sciences http://orcid.org/0000-0002-9037-8108
  • Mohammed Abdul Hannan Hazari Deccan College of Medical Sciences https://orcid.org/0000-0003-4097-7564
  • Safia Sultana Deccan College of Medical Sciences
  • Farah Fatima Deccan College of Medical Sciences
  • Syyeda Anees Deccan College of Medical Sciences
Keywords: Augmentation index, Augmentation pressure, Carotid femoral pulse wave velocity, Estrogen, Progesterone

Abstract

Physiological variation of estrogen and progesterone during menstrual cycle is well known.  They not only have an effect on blood pressure control, but also seem to have a role in regulating arterial compliance. This study was done to find out whether there are any changes in central arterial parameters during different phases of menstrual cycle. Thirty female  subjects  in the  age  group  of  18-22  years  with  normal,  regular menstrual  cycles  participated in this prospective observational study at our teaching hospital. Anthropometric parameters were recorded.  Blood pressure in all 4 limbs was recorded using cardiovascular risk analyzer-Periscope™ on Day 3rd to 5th (follicular phase), Day 12th to 14th (ovulation phase), Day 22nd to 24th (luteal phase) of their menstrual cycle. We collected blood samples during these three phases for estimation of estradiol and progesterone by ELISA technique. Analysis of variance and correlation statistics were done using SPSS 17.0 statistical software. No significant statistical changes were observed in systolic blood pressure, diastolic blood pressure, mean arterial pressure, pulse pressure, aortic systolic pressure, aortic diastolic pressure, aortic augmentation pressure, aortic index and pulse wave velocity during the three recorded phases of the menstrual cycle. There are many studies which correlate changes in peripheral artery blood pressure with different phases of menstrual cycle. But there is scarcity in data available which correlates central arterial pressures and arterial stiffness with natural hormonal variations in different phases of menstrual cycle. However, our results show that although there are subtle changes in blood pressure parameters along with estrogen and progesterone levels throughout the menstrual cycle, yet these were not statistically significant.

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Author Biographies

Nudrat Kahkashan, Deccan College of Medical Sciences

Graduate Student

Mehnaaz Sameera Arifuddin, Deccan College of Medical Sciences

Department of Physiology, Associate Professor

Mohammed Abdul Hannan Hazari, Deccan College of Medical Sciences

Department of Physiology, Professor & HOD

Safia Sultana, Deccan College of Medical Sciences

Graduate Student

Farah Fatima, Deccan College of Medical Sciences

Graduate Student

Syyeda Anees, Deccan College of Medical Sciences

Department of Biochemistry, Professor & HOD

References


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Published
2018-11-28
How to Cite
1.
Kahkashan N, Arifuddin M, Hazari M, Sultana S, Fatima F, Anees S. Variation in carotid-femoral pulse wave velocity, augmentation pressure and augmentation index during different phases of menstrual cycle. Annals of Medical Physiology [Internet]. 28Nov.2018 [cited 17Oct.2019];2(3):27-2. Available from: http://amphysiol.com/index.php/amp/article/view/v2i3.10454
Section
Original Research Articles

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