Immunoglobulin stimulatory property of aqueous leaf extract of Justicia carnea in male Wistar rats exposed to lead acetate




Humoral immunity, Immunoglobulins, Justicia carnea, Toxicity


With regards to previously speculated hematinic/hematopoietic potentials of Justicia carnea, the present study set out to evaluate the effect of the administration of the aqueous leaf extract of Justicia carnea on the immunoglobulins levels in two sets of rats (non-lead intoxicated and lead- intoxicated rats). Forty (40) male Wistar rats were obtained and randomly distributed into eight (8) groups of 5 rats each as follows: Group 1 served as negative control/received 1ml of distilled water daily; Group 2 served as positive control/treated with 10mg/ of lead acetate (Pb); Groups 3 to 5 received 400, 600 and 800mg/kg body weight of aqueous leaf extract of Justicia carnea respectively daily and Groups 6 to 8 received 400, 600 and 800mg/kg bw extract + 10mg/ Pb respectively daily.   At the end of 6 weeks of treatment, blood samples were harvested from the study animals via cardiac puncture after sedating them with 80% chloroform for laboratory analyses. The result of the present study indicated that immunoglobulins (Ig) G, M and A had significant (p<0.05) increases across all extract treated rats.  In conclusion, this study has shown that extract possess humoral immunity enhancing potential. However, extrapolating from the present study, the frequency/consumption of the high dose of the extract should be checked in its ethnobotanical application as to prevent any possible consequent undesirable effects of autoimmune conditions.


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Author Biographies

Sunday Ogbu Ojeka, University of Port Harcourt

Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences

Joy Uchenna Onyekwere, University of Port Harcourt

Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences

Onyebuchi Obia, Rivers State University

Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medicine

Dr. Mpakaboari Tonye Bekinbo, Federal University Otuoke

Department of Human Physiology, Faculty of Basic Medical Sciences


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How to Cite

Ojeka SO, Onyekwere JU, Obia O, Bekinbo MT. Immunoglobulin stimulatory property of aqueous leaf extract of Justicia carnea in male Wistar rats exposed to lead acetate. Ann Med Physiol [Internet]. 2023Oct.24 [cited 2024May28];7(1):1-7. Available from:



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