Dyslipidemia is the hallmark of the metabolic syndrome in postmenopausal women

Dyslipidemia in postmenopausal women

Authors

DOI:

https://doi.org/10.23921/amp.2020v4i2.115684

Keywords:

Estrogen, Hyperlipidemia, Insulin resistance, Postmenopausal women

Abstract

The incidence of cardiovascular diseases (CVD) increases after menopause and may be due to changes in the plasma lipid-lipoprotein levels that occur following menopausal transition. Physiological estrogen withdrawal during menopause plays a major role in abnormal lipid metabolism such as elevated low-density lipoprotein concentration. The aim of this study was to determine the relationship between dyslipidemia and the causative factors of metabolic syndrome in postmenopausal women. In this cross-sectional study, 290 postmenopausal Sudanese women were included. Lipid profiles were measured by spectrophotometer, estrogen hormone determined by ELISA, insulin resistance determined by HOMA-2 calculator and lipid accumulation product was calculated by the following equation (waist circumference in cm X triglyceride concentration in mM). The results revealed that total cholesterol, triglycerides, low-density lipoprotein levels and very low-density lipoprotein levels were significantly higher in the postmenopausal women with metabolic syndrome (MS) in comparison to those without the MS. Elevated total cholesterol levels were seen in 51.7 %, elevated triglycerides were seen in 49.7% and elevated low-density lipoprotein levels were seen in 29.3% whereas reduced high density lipoprotein levels were seen in 16.89% of the postmenopausal women. Total cholesterol, triglycerides and very low-density lipoprotein values showed a significant positive correlation with insulin resistance and lipid accumulation and a significant negative correlation with the estrogen hormone level. In addition, high density lipoproteins showed a significant negative correlation with lipid accumulation levels.

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Author Biographies

Asim Alaaeldin Osman, University of Gadarif

Department of Human Physiology

Ahmed Mohamed Fadlalla, International University of Africa

Department of Physiology

References

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Published

2020-06-30

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1.
Osman AA, Fadlalla AM. Dyslipidemia is the hallmark of the metabolic syndrome in postmenopausal women: Dyslipidemia in postmenopausal women. Ann Med Physiol [Internet]. 2020Jun.30 [cited 2020Nov.27];4(2):18-21. Available from: http://amphysiol.com/index.php/amp/article/view/v4i2.115684

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